Tienamycin

Tienamycin

Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor. Tienamycin is our hot selling product,if you are interested in it,please contact us Email:houyuan888@163.com

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Product Details

Product name: Tienamycin

CAS:64221-86-9

EINECS:264-734-5

MF:C12H17N3O4S

MW:299.34

Appearance: white or off-white powder

Assay:≥97.0%

Packing:Aluminum foil bag

Place of origin: Xinxiang,China


Tienamycin - General Information

  Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor

Pharmacology of Tienamycin

  Tienamycin is a beta-lactam antibiotic belongings to the subgroup of carbapenems. Tienamycin has a broad spectrum of activity against aerobic and anaerobic Gram positive as well as Gram negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. Tienamycin is rapidly degraded by the renal enzyme dehydropeptidase when administered alone, and is always co-administered with cilastatin to prevent this inactivation.


Additional information about Tienamycin

   Tienamycin Indication: For the treatment of bacterial infections caused by susceptible bacteria.
Mechanism Of Action: Tienamycin acts as an antimicrobial through inhibiting cell wall synthesis of various gram-positive and gram-negative bacteria. It remains very stable in the presence of beta-lactamase (both penicillinase and cephalosporinase) produced by some bacteria, and is a strong inhibitor of beta-lactamases from some gram-negative bacteria that are resistant to most beta-lactam antibiotics.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Imipenem
Synonyms: IMP; N-formimidoylthienamycin; Imipenem, n-formimidoyl thienamycin; Imipemide
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Imipenem: Tienamycin; 
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Renal.
Half Life: 1 hour
Dosage Forms of Tienamycin: Not Available
Chemical IUPAC Name: (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid


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