4-Nitrobenzyl hydrogen malonate; CAS:77359-11-6; Stable supply, competitive price and guaranteed quality Welcome to inquiry

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Product Details

Product name:  4-Nitrobenzyl hydrogen malonate


MF: C10H9NO6

Appearance: White to Slight yellow Powder



Melting point:109℃

Boiling Point: 455.8°C at 760 mmHg

Packaging Details: According to the customer's requirements.



   4-Nitrobenzyl hydrogen malonate is used to synthesize meropenem and meropenem is an artificial broad-spectrum carbapenem antibiotic, which produces antibacterial effect by inhibiting the synthesis of bacterial cell wall. Meropenem easily penetrates the cell walls of most gram-positive and negative bacteria and reaches its target of penicillin binding protein (PBPS). With the exception of metal β -lactamases, the hydrolysis of most β -lactamases (including penicillin and cephalosporinase produced by Gram-positive and Gram-negative bacteria) was stable. Meropenem is not suitable for the treatment of methicillin-resistant staphylococci infection, and sometimes cross resistance to other carbapenem resistant strains. In vitro experiments showed that meropenem combined with aminoglycoside antibiotics could produce synergistic effects on some strains isolated from Pseudomonas aeruginosa.

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