C6H8O4

C6H8O4 is the chemical formula of organic compound universally used in Knoevenagel condensations. Which is highly active in some synthesis route. Meldrum's acid is chemically 2,2-Dimethyl-m-dioxane-4,6-dione or Isopropylidene malonate. This product is a condensation product of malonic acid....

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C6H8O4 is the chemical formula of organic compound universally used in Knoevenagel condensations. Which is highly active in some synthesis route.

Meldrum's acid is chemically 2,2-Dimethyl-m-dioxane-4,6-dione or Isopropylidene malonate. This product is a condensation product of malonic acid. This compound is an oxygen analogue of barbituric acid. Like malonic acid, Meldrum's acid has reactive hydrogen atom on the carbon alpha to both carbonyl groups. Meldrum's acid undergoes Knoevenagel condensation reaction as a reactant to forms condensed products. Knoevenagel condensation is a nucleophilic addition of a reactive hydrogen atom at 1,3-diketone compounds to a carbonyl group, followed by an dehydration reaction. 1,3-Diketone compounds (beta-ketones) include malonic acid, diethyl malonate, Meldrum's acid, barbituric acid, and acetoacetic acid derivatives.


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