CAS:82009-34-5

CAS:82009-34-5

Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.

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Product Details

Product name:Cilastatin acid

CAS:82009-34-5

Synonyms:(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid; MK-791;

Molecular form.:C₁₆H₂₆N₂O₅S

Appearance:White to Light Yellow Solid

Melting Point:>144ºC (dec.)

Mol. Weight:358.45

Applications:Cilastatin prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. It is an antibacterial adjunct.

Place of origin: Xinxiang China


Description:

  Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.1 It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM).1,2,3 Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin (Item No. 15327).4 In a mouse model of systemic infection, cilastatin in combination with imipenem (Item No. 16039) protects mice from S. aureus, E. coli, and P. aeruginosa infection.5 Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life.2 Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.


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FAQ

Q2: Which payment terms do you accept? 

A2: L/C, T/T, D/A, D/P, Western Union, MoneyGram, Paypal are available.But different payment terms against countries.

Q3: What's about the MOQ ?

A3: It depends on different products.Usually our MOQ is 1kg. 

Q4: What’s the delivery lead time?

A4: We will make delivery within 7 days after receiving payment. 

Q5: What about the delivery port? 

A5: Main ports in China are available.


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