6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium Chloride

6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium Chloride

Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics,our company specializes in penem intermedicate ,please inquiry us anytime!

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Product Details

Product name: 6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride

CAS: 153851-71-9

MF: C5H8ClN3S

Purity: 99.5%

Test method: HPLC

Appearance: white crystalline powde

Package:25kg/drums

Appearance: white to yellowish crystalline powder
Determination of content: 98%

Specific rotation:-26.0℃ to 36℃

pH: 4.5 to 6.0

Single Impurity: <1.0%

Total Impurities: <3.0%


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Overview

Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics. Biapenem (LJC 10627) is a carbapenem antibiotic for injection developed by Japanese Lederle Company and American Cyanamid Company in 1989. It is now completed in Phase III clinical studies in Japan and waits for approval. The most significant feature of this product is that the S in 2-position has bicyclic triazole 1β-methyl carbapenem. The study of structure-activity relationship shows that the presence of the side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, so that its ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria is 2~4 times that of imipenem, its ability to inhibit the activity of drug-resistant pseudomonas aeruginosa is 4 to 8 times that of Meropenem, and its effect on acinetobacter and anaerobic bacteria is more effective than ceftazidime.





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