Mono-4-nitrobenzylmalonicacidester And Meropenem

- Jan 26, 2019 -

 Mono-4-nitrobenzylmalonicacidester is uesed for the synthesis of meropenem

Meropenem, an artificial broad-spectrum carbapenem antibiotic, produces antibacterial effects by inhibiting the synthesis of bacterial cell walls, and meropenem easily penetrates the cell walls of most gram-positive and negative bacteria. But to reach its target point penicillin binding protein (PBPS). With the exception of metal β -lactamases, the hydrolysis of most β -lactamases (including penicillin and cephalosporinase produced by Gram-positive and Gram-negative bacteria) was stable. Meropenem is not suitable for the treatment of methicillin-resistant staphylococci infection, and sometimes cross resistance to other carbapenem resistant strains. In vitro experiments showed that meropenem combined with aminoglycoside antibiotics could produce synergistic effects on some strains isolated from Pseudomonas aeruginosa.

Mono-4-nitrobenzylmalonicacideste plays an important role in the synthesis of meropenem.

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