Isopropylidene Malonate Malonic Acid Cyclic Isopropylidene Ester And Sitagliptin

- Jan 24, 2019 -

 In the process of synthesizing the intermediate of Sitagliptin, Isopropylidene Malonate Malonic Acid Cyclic Isopropylidene Ester is used as the starting material and other intermediates, in a step by step reaction, to produce cilastatin. Isopropylidene Malonate Malonic Acid Cyclic Isopropylidene Ester  was obtained by the reaction of malonic acid and acetone with concentrated sulfuric acid and acetic anhydride.Isopropylidene Malonate Malonic Acid Cyclic Isopropylidene Ester is synthesized by condensation of malonic acid and acetone in acetic anhydride catalyzed by sulfuric acid to form maleic acid and dicarboxylic acid.

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