Fluoropyridine Intermediates Become Hot Spots

- Apr 19, 2018 -

At present, our country has developed and has been engaged in batch production of quinolone antibacterial drugs mainly norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomax, fluroxacin, etc. Norfloxacin, ciprofloxacin, and ofloxacin are the largest, accounting for 98% of the total production of fluoroquinolones.

Quinolones are usually synthesized from fluorophenol with piperazine (or methyl piperazine) after synthesis of fluoroquinoline compounds. Due to the abundant fluorite reserves in our country, it is one of the countries with the largest production of fluorine drugs and intermediates in the world, and more than 80% of the fluorine-containing intermediates are exported. On the whole, the development of fluorobenzene intermediates in China is early, and there is a general surplus of production capacity. Trifluorotoluene intermediates developed late and developed rapidly in recent years. For heterocyclic aromatic compounds especially fluoride pyridine class, our country at present, the only individual research units and the manufacturer has a fluoride pyridine intermediates in the synthesis technology, therefore, fluoride pyridine intermediates will be in the next few years one of the main direction of research and development of domestic fluorine-contained intermediates.

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