New synthetic peptide treatment for AIDS: viral load reduced by 99% in 4 weeks

- Nov 06, 2018 -

   Gammora is a synthetic peptide compound derived from the HIV integrase, which is responsible for inserting the virus's genetic material into the DNA of infected cells.The drug stimulates the integration of multiple strands of HIV DNA into the host cell's genomic DNA until it reaches the point of triggering the self-destruction of the infected cell, known as apoptosis.Gammora, manufactured by PolyPeptide Labs in San Diego, California, has the potential to cure people with HIV by destroying all cells that carry the HIV genome.Currently available antiretroviral drugs, known as "cocktail" treatments, can only inhibit virus replication and transmission, but not cure infection.

   From July to August 2018, Zion Medical conducted an I/IIa phase I clinical study of Gammora, which again confirmed previous clinical results that the drug is safe and effective in killing hiv-infected cells.In the first part of the study, nine hiv-infected patients at the Ronald bata memorial hospital in Uganda were randomly assigned to the Gammora treatment group of 0.05-0.2mg/kg, 0.1-0.3mg/kg or 0.2-0.4mg/kg for a course of 4-5 weeks.Within the first four weeks, most patients had a significant 90 percent reduction in viral load relative to baseline.

    2 weeks after completion of the first part, the second part of the study was performed, with patients receiving Gammora and other antiretroviral drugs combined for 4-5 weeks, receiving lopinavir/ritonavir, LPV+r, 800mg/200mg/week combined with Gammora (0.2-0.4mg/kg) twice a week, or receiving only LPV+r.The results showed that the combined treatment group showed persistent virological inhibition and reached hiv-1 RNA < 300 copies /mL, and the HIV viral load decreased by 99% from baseline within 4 weeks.

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