- Oct 11, 2018 -
Meropenem is an ultra-broad-spectrum injectable antibiotic used to treat a wide variety of infections. It is a beta-lactam and belongs to the subgroup ofcarbapenem, similar to imipenem and ertapenem. Meropenem was originally developed by Dainippon Sumitomo Pharma.It gained US FDA approval in July 1996. It penetrates well into many tissues and body fluids including thecerebrospinal fluid, bile, heart valves, lung, and peritoneal fluid.
The spectrum of action includes many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. The overall spectrum is similar to that of imipenem, although meropenem is more active againstEnterobacteriaceae and less active against Gram-positive bacteria. It is also very resistant to extended-spectrum beta lactamases but may be more susceptible to metallo-beta-lactamases. Meropenem is frequently given in the treatment of febrile neutropenia. This condition frequently occurs in patients withhematological malignancies and cancer patients receiving anticancer drugs that cause bone marrow suppression. It is approved for complicated skin and skin structure infections, complicated intra-abdominal infections and bacterial meningitis.