3-(2-bromopropanoyl)spiro[13-benzoxazine-21'-cyclohexane]-4-one158299-05-9

- Jul 02, 2018 -

  Meropenem is another semi-synthetic carbapenem antibiotic administered parenterally after imipenem-cilastatin is marketed in the United States. Through its covalent bond and the participation of cell wall synthesis of penicillin binding proteins (PBPs) binding inhibition of bacterial cell wall synthesis, thus antibacterial effect. Gram-positive bacteria, Gram-negative bacteria are sensitive, especially for Gram-negative bacteria have a strong antibacterial activity. (MIC <4mg / L), the total inhibitory concentration (MIC) of about 90% of Enterobacteriaceae was 0.08-0.15mg / L, 90% Including ampicillin resistant strains were highly sensitive (MIC 0.06-1mg / L). Neisseria gonorrhoeae is also highly sensitive to meropenem, its activity is stronger than imipenem 15 times. Staphylococcus epidermidis, S. saprophyticus and other coagulase-negative staphylococci are susceptible to meropenem and most strains of Enterococcus faecalis are highly or moderately sensitive to meropenem. Meropenem at a MIC of 0.06-4 mg / L inhibited almost all of Bacteroides fragilis. Anaerobes such as Streptococcus, Propionibacterium, actinomycetes, etc. are also sensitive to meropenem.

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